Биологическая активность
Rilmenidine, an innovative antihypertensive agent, is an orally active, селективный I1 imidazoline рецептор агонист. Rilmenidine is an alpha 2-adrenoceptor агонист. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells.
Оригинал на английском
Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells.
Химические свойства
- CAS №
- 54187-04-1
- Брутто-формула
- C₁₀H₁₆N₂O
- Мол. масса
- 180.25 г/моль
- SMILES
- C1(NC(C2CC2)C3CC3)=NCCO1
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- Please store the product under the recommended conditions in the Certificate of Analysis.
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.