Биологическая активность
(R)-AM1241 acts as an агонист at human CB2 receptors but an inverse агонист at rat and mouse CB2 receptors. Similar to the racemate AM1241, (R)-AM1241 produces antinociception to thermal pain but not mechanical pain in rats. The pain-reducing effect of (R)-AM1241 is blocked by the CB2-specific ингибитор SR 144528 but not by either the CB1-селективный ингибитор rimonabant or the opioid рецептор blocker naloxone.
Оригинал на английском
(R)-AM1241 acts as an agonist at human CB2 receptors but an inverse agonist at rat and mouse CB2 receptors. Similar to the racemate AM1241, (R)-AM1241 produces antinociception to thermal pain but not mechanical pain in rats. The pain-reducing effect of (R)-AM1241 is blocked by the CB2-specific inhibitor SR 144528 but not by either the CB1-selective inhibitor rimonabant or the opioid receptor blocker naloxone.
Химические свойства
- Брутто-формула
- C₂₂H₂₂In₃O₃
- Мол. масса
- 503.34 г/моль
- SMILES
- CN1CCCC[C@@H]1Cn2cc(c3c2cccc3)C(=O)c4cc(ccc4I)[N+](=O)[O-]
- Синонимы
- AM-1241, (R)-; (R)-AM1241; (R)-AM-1241
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.