Биологическая активность
Phlorizin, also referred to as phloridzin, is a glucoside of phloretin, a dihydrochalcone, a family of bicyclic flavonoids, which in turn is a subgroup in the diverse phenylpropanoid synthesis pathway in plants. Phlorizin is a competitive ингибитор of SGLT1 and SGLT2 because it competes with D-glucose for связывание to the carrier; this reduces renal glucose transport, lowering the amount of glucose in the blood. Phlorizin was studied as a potential pharmaceutical treatment for type 2 diabetes, but has since been superseded by more селективный and more promising synthetic analogs, such as canagliflozin and dapagliflozin.
Оригинал на английском
Phlorizin, also referred to as phloridzin, is a glucoside of phloretin, a dihydrochalcone, a family of bicyclic flavonoids, which in turn is a subgroup in the diverse phenylpropanoid synthesis pathway in plants. Phlorizin is a competitive inhibitor of SGLT1 and SGLT2 because it competes with D-glucose for binding to the carrier; this reduces renal glucose transport, lowering the amount of glucose in the blood. Phlorizin was studied as a potential pharmaceutical treatment for type 2 diabetes, but has since been superseded by more selective and more promising synthetic analogs, such as canagliflozin and dapagliflozin.
Химические свойства
- CAS №
- 60-81-1
- Брутто-формула
- C₂₁H₂₄O₁₀
- Мол. масса
- 436.41 г/моль
- Синонимы
- Phlorizin; phloridzin; phloretin-2'-β-D-glucopyranoside; AI3-19835; NSC 2833 и ещё 4
Безопасность и документация
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