Биологическая активность
PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome ингибитор. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB ингибитор IκBα by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice.
Оригинал на английском
PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice.
Химические свойства
- CAS №
- 139637-11-9
- Брутто-формула
- C₂₂₉H₃₄₆N₇₀O₄₀
- Мол. масса
- 4719.74 г/моль
- Синонимы
- RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP-NH2
Хранение и физические свойства
- Условия хранения
- Please store the product under the recommended conditions in the Certificate of Analysis.
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.