Биологическая активность
PPACK is a synthetic peptide derivative that irreversibly and specifically inhibits thrombin-mediated platelet activation by связывание with high affinity to the active site of thrombin (Ki = 0.24 nM). It has been used as an anticoagulant (100 μM) and to study thrombin-mediated fibrin deposition, angiogenesis, and proinflammatory processes.
Оригинал на английском
PPACK is a synthetic peptide derivative that irreversibly and specifically inhibits thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki = 0.24 nM). It has been used as an anticoagulant (100 μM) and to study thrombin-mediated fibrin deposition, angiogenesis, and proinflammatory processes.
Химические свойства
- Брутто-формула
- C₂₁H₃₁ClN₆O₃
- Мол. масса
- 450.96 г/моль
- SMILES
- O=C(N[C@H](C(CCl)=O)CCCNC(N)=N)[C@H]1N(C([C@@H](CC2=CC=CC=C2)N)=O)CCC1
- Синонимы
- PPACK; D-Phe-pro-arg CH2Cl
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.