Биологическая активность
Norharmane is a β-Carboline alkaloid that is widespread in plants and animals, and frequently act as benzodiazepine inverse agonists. Norharmane showed a мощный inhibition against α-glucosidase enzyme in a concentration dependent manner with an IC50 value of 0.27 mM for maltase and 0.41 mM for sucrase, respectively. A Lineweaver-Burk plot revealed that norharman inhibited α-glucosidase enzyme uncompetitively, with a Ki value of 0.13 mM.
Оригинал на английском
Norharmane is a β-Carboline alkaloid that is widespread in plants and animals, and frequently act as benzodiazepine inverse agonists. Norharmane showed a potent inhibition against α-glucosidase enzyme in a concentration dependent manner with an IC50 value of 0.27 mM for maltase and 0.41 mM for sucrase, respectively. A Lineweaver-Burk plot revealed that norharman inhibited α-glucosidase enzyme uncompetitively, with a Ki value of 0.13 mM.
Химические свойства
- CAS №
- 244-63-3
- Брутто-формула
- C₁₁H₈N₂
- Мол. масса
- 168.20 г/моль
- SMILES
- C(N1)(C=NC=C2)=C2C3=C1C=CC=C3
- Синонимы
- Norharmane; β-Carboline; 2-Azacarbazole.
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.