Биологическая активность
Trioxsalen is a photosenisitizer. It is obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed клетка death unless repaired by клеточный mechanisms. In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage.
Оригинал на английском
Trioxsalen is a photosenisitizer. It is obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death unless repaired by cellular mechanisms. In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage.
Химические свойства
- CAS №
- 3902-71-4
- Брутто-формула
- C₁₄H₁₂O₃
- Мол. масса
- 228.25 г/моль
- SMILES
- CC1=CC2=CC3=C(OC(=O)C=C3C)C(C)=C2O1
- Синонимы
- NSC71047; NSC-71047; NSC 71047; Trioxsalen, trimethylpsoralen, Trioxysalen; Trisoralen.
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.