Биологическая активность
Cytochalasin E is a natural autophagy ингибитор which enhances chemotherapy-induced клетка death. Cytochalasin E is an epoxide-containing analog of Cytochalasin B which potently and selectively inhibits the growth of endothelial cells, thereby impairing angiogenesis and tumor growth. Unlike Cytochalasin A and Cytochalasin B, it does not inhibit glucose transport.
Оригинал на английском
Cytochalasin E is a natural autophagy inhibitor which enhances chemotherapy-induced cell death. Cytochalasin E is an epoxide-containing analog of Cytochalasin B which potently and selectively inhibits the growth of endothelial cells, thereby impairing angiogenesis and tumor growth. Unlike Cytochalasin A and Cytochalasin B, it does not inhibit glucose transport.
Химические свойства
- Брутто-формула
- C₃₀H₃₇NO₇
- Мол. масса
- 523.63 г/моль
- SMILES
- O=C(O/C=C/[C@@](O)(C1=O)C)OC23[C@@]([H])(/C=C/C[C@@]1(C)[H])[C@H]4[C@](O4)([C@H]([C@]2([C@@H](NC3=O)CC5=CC=CC=C5)[H])C)C
- Синонимы
- NSC-175151; NSC 175151; NSC175151; Cytochalasin E
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.