Биологическая активность
Mabuterol is a селективный β2 adrenoreceptor агонист. Mabuterol has a specific effect on beta 2-adrenoceptors with no beta 1-stimulation. Mabuterol inhibited the positive inotropic effect of isoprenaline at 10(-7) g/ml and decreased the maximum driving frequency at 3 X 10(-6) g/ml. Mabuterol was 3 times more мощный in relaxing the isolated rat uterus, but 700 times less мощный than isoprenaline in relaxing the rabbit jejunum. Mabuterol (p.o.) depressed the intestinal propulsion and was equipotent to isoprenaline and 2.5 times less мощный than salbutamol.
Оригинал на английском
Mabuterol is a selective β2 adrenoreceptor agonist. Mabuterol has a specific effect on beta 2-adrenoceptors with no beta 1-stimulation. Mabuterol inhibited the positive inotropic effect of isoprenaline at 10(-7) g/ml and decreased the maximum driving frequency at 3 X 10(-6) g/ml. Mabuterol was 3 times more potent in relaxing the isolated rat uterus, but 700 times less potent than isoprenaline in relaxing the rabbit jejunum. Mabuterol (p.o.) depressed the intestinal propulsion and was equipotent to isoprenaline and 2.5 times less potent than salbutamol.
Химические свойства
- CAS №
- 56341-08-3
- Брутто-формула
- C₁₃H₁₈ClF₃N₂O
- Мол. масса
- 310.75 г/моль
- Синонимы
- Mabuterol; PB 868Cl
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.