Биологическая активность
Levolansoprazole is a proton pump ингибитор that irreversibly inhibits H+/K±stimulated ATPase pumps in parietal cells (IC50 = 5.2 μM), inhibiting gastric acid secretion and increasing intragastric pH. It also inhibits acid formation in isolated canine parietal cells (IC50 = 82 μM). Lansoprazole is an enantiomerically pure form of lansoprazole. Both (S)- and (R)-lansoprazole are pharmacologically active with similar potencies.
Оригинал на английском
Levolansoprazole is a proton pump inhibitor that irreversibly inhibits H+/K±stimulated ATPase pumps in parietal cells (IC50 = 5.2 μM), inhibiting gastric acid secretion and increasing intragastric pH. It also inhibits acid formation in isolated canine parietal cells (IC50 = 82 μM). Lansoprazole is an enantiomerically pure form of lansoprazole. Both (S)- and (R)-lansoprazole are pharmacologically active with similar potencies.
Химические свойства
- Брутто-формула
- C₁₆H₁₄F₃N₃O₂S
- Мол. масса
- 369.36 г/моль
- SMILES
- Cc1c(C[S@@](c([nH]2)nc3c2cccc3)=O)nccc1OCC(F)(F)F
- Синонимы
- Levolansoprazole; (S)-Lansoprazole; (-)-Lansoprazole
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.