Биологическая активность
KU59403 is a мощный and селективный ATM (Ataxia telangiectasia mutated) ингибитор with with potential anticancer activity. KU59403 was not cytotoxic to human cancer клетка lines (SW620, LoVo, HCT116, and MDA-MB-231) per se but significantly increased the cytotoxicity of topoisomerase I and II poisons: camptothecin, etoposide, and doxorubicin. KU59403 significantly enhanced the antitumor activity of topoisomerase poisons in mice bearing human colon cancer xenografts (SW620 and HCT116) at doses that were nontoxic alone and well-tolerated in combination
Оригинал на английском
KU59403 is a potent and selective ATM (Ataxia telangiectasia mutated) inhibitor with with potential anticancer activity. KU59403 was not cytotoxic to human cancer cell lines (SW620, LoVo, HCT116, and MDA-MB-231) per se but significantly increased the cytotoxicity of topoisomerase I and II poisons: camptothecin, etoposide, and doxorubicin. KU59403 significantly enhanced the antitumor activity of topoisomerase poisons in mice bearing human colon cancer xenografts (SW620 and HCT116) at doses that were nontoxic alone and well-tolerated in combination
Химические свойства
- CAS №
- 845932-30-1
- Брутто-формула
- C₂₉H₃₂N₄O₄S₂
- Мол. масса
- 564.72 г/моль
- SMILES
- O=C(CCN1CCN(C)CC1)NC2=CC3=C(SC(C(C4=CC(C=C(N5CCOCC5)O4)=O)=CC=C6)=C6S3)C=C2.
- Синонимы
- KU59403; KU-59403; KU 59403
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.