Биологическая активность
Taltobulin, also known as HTI-286 and SPA-110, is a fully synthetic analog of the natural tripeptide hemiasterlin, inhibits tubulin polymerization and circumvents transport-based resistance to taxanes. HTI-286 was a мощный ингибитор of proliferation (mean IC50 = 2.5 ?± 2.1 nm in 18 human tumor клетка lines) and had substantially less interaction with multidrug resistance protein (P-glycoprotein) than currently used antimicrotubule agents, including paclitaxel, docetaxel, vinorelbine, or vinblastine.
Оригинал на английском
Taltobulin, also known as HTI-286 and SPA-110, is a fully synthetic analog of the natural tripeptide hemiasterlin, inhibits tubulin polymerization and circumvents transport-based resistance to taxanes. HTI-286 was a potent inhibitor of proliferation (mean IC50 = 2.5 ?± 2.1 nm in 18 human tumor cell lines) and had substantially less interaction with multidrug resistance protein (P-glycoprotein) than currently used antimicrotubule agents, including paclitaxel, docetaxel, vinorelbine, or vinblastine.
Химические свойства
- CAS №
- 228266-40-8
- Брутто-формула
- C₂₇H₄₃N₃O₄
- Мол. масса
- 473.65 г/моль
- SMILES
- CC(C)(C)[C@@H](C(NC([C@H](C(C)(C)C1=CC=CC=C1)NC)=O)=O)N([C@@H](C(C)C)/C=C(C(O)=O)\C)C
- Синонимы
- HTI-286, HTI 286, HTI286, SPA-110, SPA110, SPA 110, Taltobulin
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.