Биологическая активность
Apoptone, also known as HE3235, is an orally bioavailable adrenal steroid analogue with potential antineoplastic activity. Androstane steroid HE3235 appears to bind the androgen рецептор (AR), down-regulating anti-apoptotic genes, such as Bcl-2, while increasing the expression of pro-apoptotic genes, such as caspases. in vitro and in vivo studies indicate that this agent inhibits androstenediol-dependent LNCaP клетка tumor growth. In addition, HE3235 may potentiate chemotherapeutic agents by down-regulating ABCG2, the gene encoding the multi-препарат resistant (MDR) protein MDR2.
Оригинал на английском
Apoptone, also known as HE3235, is an orally bioavailable adrenal steroid analogue with potential antineoplastic activity. Androstane steroid HE3235 appears to bind the androgen receptor (AR), down-regulating anti-apoptotic genes, such as Bcl-2, while increasing the expression of pro-apoptotic genes, such as caspases. In vitro and in vivo studies indicate that this agent inhibits androstenediol-dependent LNCaP cell tumor growth. In addition, HE3235 may potentiate chemotherapeutic agents by down-regulating ABCG2, the gene encoding the multi-drug resistant (MDR) protein MDR2.
Химические свойства
- CAS №
- 183387-50-0
- Брутто-формула
- C₂₁H₃₂O₂
- Мол. масса
- 316.48 г/моль
- SMILES
- O[C@@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@](O)(C#C)CC[C@@]4([H])[C@]3([H])CC[C@@]2([H])C1
- Синонимы
- HE3235, HE-3235, HE3235, Apotone
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.