Биологическая активность
GSK864 is a мощный and селективный ингибитор of mutant IDH1. GSK864 inhibits IDH1 mutants R132C/R132H/R132G с IC50 values of 9/15/17 nM, respectively, and is moderately селективный over wild-type IDH1 and IDH2 mutants/wild-type. Treatment of R132C IDH1 mutant HT-1080 cells for 24 hours with GSK864 results in a dose-dependent reduction of 2-hydroxyglutarate (2-HG), which is not observed with GSK990, a structurally similar compound which is inactive as an IDH1 ингибитор. GSK864 has been shown to be селективный in vitro for IDH1 over other classes of proteins (7TMs, ion channels, kinases) and chemoproteomic studies with GSK321, an analog of GSK864, confirm селективный связывание of IDH1 by this chemical series. GSK864 has a pharmacokinetic profile suitable for in vivo studies.
Оригинал на английском
GSK864 is a potent and selective inhibitor of mutant IDH1. GSK864 inhibits IDH1 mutants R132C/R132H/R132G with IC50 values of 9/15/17 nM, respectively, and is moderately selective over wild-type IDH1 and IDH2 mutants/wild-type. Treatment of R132C IDH1 mutant HT-1080 cells for 24 hours with GSK864 results in a dose-dependent reduction of 2-hydroxyglutarate (2-HG), which is not observed with GSK990, a structurally similar compound which is inactive as an IDH1 inhibitor. GSK864 has been shown to be selective in vitro for IDH1 over other classes of proteins (7TMs, ion channels, kinases) and chemoproteomic studies with GSK321, an analog of GSK864, confirm selective binding of IDH1 by this chemical series. GSK864 has a pharmacokinetic profile suitable for in vivo studies.
Химические свойства
- CAS №
- 1816331-66-4
- Брутто-формула
- C₃₀H₃₁FN₆O₄
- Мол. масса
- 558.60 г/моль
- SMILES
- FC1=CC=C(CN2C3C(CN(CC=3C(C(=O)NC3C=C(C)C(OC)=C(C)C=3)=N2)C(=O)C2NC=CC=2)(C)C(=O)N)C=C1
- Синонимы
- GSK864; GSK-864
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.