Биологическая активность
GSK-2881078 is an orally active and nonsteroidal селективный androgen рецептор modulator (SARM) which act as partial AR agonists in androgenic tissues while mainly as complete AR agonists in synthetic metabolic tissues,induces AR-mediated transcriptional activation in PC3(AR)2 cells (EC50 = 3.99 nM) and the effect can be inhibited by the non-steroidal AR антагонист Bicalutamide. GSK-2881078 can be used in research of muscle weakness and cachexia associated with both chronic and acute illness.
Оригинал на английском
GSK-2881078 is an orally active and nonsteroidal selective androgen receptor modulator (SARM) which act as partial AR agonists in androgenic tissues while mainly as complete AR agonists in synthetic metabolic tissues,induces AR-mediated transcriptional activation in PC3(AR)2 cells (EC50 = 3.99 nM) and the effect can be inhibited by the non-steroidal AR antagonist Bicalutamide. GSK-2881078 can be used in research of muscle weakness and cachexia associated with both chronic and acute illness.
Химические свойства
- CAS №
- 1539314-06-1
- Брутто-формула
- C₁₄H₁₃F₃N₂O₂S
- Мол. масса
- 330.33 г/моль
- SMILES
- S(C([H])([H])[H])(C([H])([H])C([H])(C([H])([H])[H])N1C([H])=C([H])C2C(C(F)(F)F)=C(C#N)C([H])=C([H])C1=2)(=O)=O
- Синонимы
- GSK-2881078; GSK2881078; BCP20210; GSK 2881078; 1-(1-methylsulfonylpropan-2-yl)-4-(trifluoromethyl)indole-5-carbonitrile
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.