Биологическая активность
Fialuridine, also known as FIAU, DRG-0098, is a DNA-directed DNA polymerase ингибитор potentially for the treatment of HBV infection. Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic препарат toxicity prior to human testing. Fialuridine is phosphorylated and inhibits DNA synthesis in isolated rat hepatic mitochondria. Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts.
Оригинал на английском
Fialuridine, also known as FIAU, DRG-0098, is a DNA-directed DNA polymerase inhibitor potentially for the treatment of HBV infection. Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing. Fialuridine is phosphorylated and inhibits DNA synthesis in isolated rat hepatic mitochondria. Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts.
Химические свойства
- CAS №
- 69123-98-4
- Брутто-формула
- C₉H₁₀FIn₂O₅
- Мол. масса
- 372.09 г/моль
- SMILES
- O=C1NC(C(I)=CN1[C@H]2[C@@H](F)[C@@H]([C@@H](CO)O2)O)=O
- Синонимы
- Fialuridine; FIAU; DRG-0098; DRG-0098; DRG-0098 и ещё 1
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.