Биологическая активность
Crolibulin, also known as EPC2407 and crinobulin, is a малая молекула tubulin polymerization ингибитор with potential antineoplastic activity. Microtubulin ингибитор EPC2407 binds to the colchicine-связывание site on beta-tubulin and inhibits the polymerization of tubulin into microtubules, which may result in клетка cycle arrest, the induction of apoptosis, and the inhibition of tumor клетка proliferation. As a vascular disruption agent (VDA), this agent also disrupts tumor neovascularization, which may result in a reduction in tumor blood flow and tumor hypoxia and ischemic necrosis.
Оригинал на английском
Crolibulin, also known as EPC2407 and crinobulin, is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. Microtubulin inhibitor EPC2407 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of tubulin into microtubules, which may result in cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. As a vascular disruption agent (VDA), this agent also disrupts tumor neovascularization, which may result in a reduction in tumor blood flow and tumor hypoxia and ischemic necrosis.
Химические свойства
- CAS №
- 1000852-17-4
- Брутто-формула
- C₁₈H₁₇BrN₄O₃
- Мол. масса
- 417.26 г/моль
- SMILES
- N#CC1=C(N)OC2=C(C=CC(N)=C2N)[C@H]1C3=CC(OC)=C(OC)C(Br)=C3
- Синонимы
- EPC2407; EPC 2407; EPC-2407; Crolibulin crinobulin.
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.