Биологическая активность
Domiphen bromide is a quaternary antiseptic used as an antifungal agent. Domiphen bromide has мощный activity on blockade of human ether-a-go-go related gene (HERG) channels. Domiphen bromide inhibited HERG channel currents in a dose-dependent manner с IC50 values of 9nM. Block of HERG channel by domiphen bromide was voltage-dependent and use-dependent. Domiphen bromide caused substantial negative shift of the activation curves, accelerated activated process, but had no effects on the deactivation and reactivation processes.
Оригинал на английском
Domiphen bromide is a quaternary antiseptic used as an antifungal agent. Domiphen bromide has potent activity on blockade of human ether-a-go-go related gene (HERG) channels. Domiphen bromide inhibited HERG channel currents in a dose-dependent manner with IC50 values of 9nM. Block of HERG channel by domiphen bromide was voltage-dependent and use-dependent. Domiphen bromide caused substantial negative shift of the activation curves, accelerated activated process, but had no effects on the deactivation and reactivation processes.
Химические свойства
- CAS №
- 538-71-6
- Брутто-формула
- C₂₂H₄₀BrNO
- Мол. масса
- 414.47 г/моль
- Синонимы
- Domiphen, Domiphen Br, Domiphen bromide, Bradasol, Fungitex, Oradol
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.