Биологическая активность
Diazinon is a cholinesterase ингибитор that is used as an organothiophosphorus insecticide. Diazinon is active against approximately 120 species of insects and pests.1 It is metabolized into the cholinesterase inhibitors monothionotetraethyl pyrophosphate, dithionotetraethyl pyrophosphate, and triethylthionophosphate in vivo, which induce vomiting, fasciculation with muscular twitching, paralysis, and death (LD50 = 125 mg/kg) in rats. Diazinon induces formation of capsular adhesion in the kidneys and ulcer formation in the duodenum of dogs as well as mucosal erosion and serosal seepage in the intestines of mini pigs. Formulations containing diazinon were previously used as agricultural pesticides.
Оригинал на английском
Diazinon is a cholinesterase inhibitor that is used as an organothiophosphorus insecticide. Diazinon is active against approximately 120 species of insects and pests.1 It is metabolized into the cholinesterase inhibitors monothionotetraethyl pyrophosphate, dithionotetraethyl pyrophosphate, and triethylthionophosphate in vivo, which induce vomiting, fasciculation with muscular twitching, paralysis, and death (LD50 = 125 mg/kg) in rats. Diazinon induces formation of capsular adhesion in the kidneys and ulcer formation in the duodenum of dogs as well as mucosal erosion and serosal seepage in the intestines of mini pigs. Formulations containing diazinon were previously used as agricultural pesticides.
Химические свойства
- Брутто-формула
- C₁₂H₂₁N₂O₃PS
- Мол. масса
- 304.34 г/моль
- SMILES
- CC1=CC(OP(OCC)(OCC)=S)=NC(C(C)C)=N1
- Синонимы
- Diazinon; Diazitol; Dicid; Diazol; Dimpylate
3D-структура молекулы
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Безопасность и документация
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