Биологическая активность
A1T2C3 （CP-LC-1067） is a highly мощный ионизируемый липид designed for lung-таргетный мРНК доставка. When formulated into липид nanoparticles (LNPs), it produces particles approximately 80 nm in size with excellent uniformity and a high мРНК encapsulation efficiency (>94%). Its most distinguished feature is its exceptional organ selectivity. Following intravenous administration in mice, A1T2C3-based LNPs demonstrated a remarkable accumulation of over 94% of the signal in the lungs, with minimal distribution to other major organs. This makes it a leading candidate for developing therapeutics specifically таргетный to pulmonary tissues.
Оригинал на английском
A1T2C3 （CP-LC-1067） is a highly potent ionizable lipid designed for lung-targeted mRNA delivery. When formulated into lipid nanoparticles (LNPs), it produces particles approximately 80 nm in size with excellent uniformity and a high mRNA encapsulation efficiency (>94%). Its most distinguished feature is its exceptional organ selectivity. Following intravenous administration in mice, A1T2C3-based LNPs demonstrated a remarkable accumulation of over 94% of the signal in the lungs, with minimal distribution to other major organs. This makes it a leading candidate for developing therapeutics specifically targeted to pulmonary tissues.
Химические свойства
- CAS №
- 3091879-17-0
- Брутто-формула
- C₅₄H₁₀₃N₃O₈S₃
- Мол. масса
- 1018.61 г/моль
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.