Биологическая активность
ионизируемый липид 4 is an ионизируемый cationic липид (pKa = 6.1) and a hydrogen peroxide-induced rearrangement product of the cationic липид CA-липид 5.1 Charge-altering липид nanoparticles (CALNPs) containing CA-липид 5 and encapsulating siRNA against EGFP undergo hydrogen peroxide-induced removal of the phenylboronic acid groups from CA-липид 5 in MCF-7 cells in vitro, generating ионизируемый липид 4-containing LNPs with reduced positive charges at physiological pH, facilitating intracellular siRNA release and gene silencing. LNPs containing ионизируемый липид 4 and encapsulating siRNA against PLK1 reduce tumor volume in an MCF-7 mouse xenograft model less effectively than CALNPs containing CA-липид 5.
Оригинал на английском
Ionizable lipid 4 is an ionizable cationic lipid (pKa = 6.1) and a hydrogen peroxide-induced rearrangement product of the cationic lipid CA-lipid 5.1 Charge-altering lipid nanoparticles (CALNPs) containing CA-lipid 5 and encapsulating siRNA against EGFP undergo hydrogen peroxide-induced removal of the phenylboronic acid groups from CA-lipid 5 in MCF-7 cells in vitro, generating ionizable lipid 4-containing LNPs with reduced positive charges at physiological pH, facilitating intracellular siRNA release and gene silencing. LNPs containing ionizable lipid 4 and encapsulating siRNA against PLK1 reduce tumor volume in an MCF-7 mouse xenograft model less effectively than CALNPs containing CA-lipid 5.
Химические свойства
- CAS №
- 1799316-81-6
- Брутто-формула
- C₄₈H₈₅NO₇
- Мол. масса
- 788.20 г/моль
- SMILES
- CCCCC/C=C\C/C=C\CCCCCCCC(OCC(COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(OCCCN(CC)CC)=O)=O
- Синонимы
- 9,12-octadecadienoic acid, (9Z,12Z)-1,1′-[2-[[[[3-(diethylamino)propoxy]carbonyl]oxy]methyl]-1,3-propanediyl] ester,Ionizable Lipid-4
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.