Биологическая активность
Cantuzumab mertansine (SB-408075; huC242-DM1), an ADC, is an immunoconjugate of the мощный maytansine derivative (DM1; HY-19792) and the humanized моноклональный антитело (huC242) directed to CanAg. Cantuzumab mertansine has cytotoxic toward colon cancer cells and has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts[1][2].
Оригинал на английском
Cantuzumab mertansine (SB-408075; huC242-DM1), an ADC, is an immunoconjugate of the potent maytansine derivative (DM1; HY-19792) and the humanized monoclonal antibody (huC242) directed to CanAg. Cantuzumab mertansine has cytotoxic toward colon cancer cells and has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts[1][2].
Химические свойства
- CAS №
- 400010-39-1
- Синонимы
- Immunoglobulin G1,anti-(mucin CanAg) (human-mouse monoclonal C242 heavy chain), disulfide withhuman-mouse monoclonal C242 light chain, dimer, tetraamide withN2'-[3-[(3-carboxy-1-methylpropyl)dithio]-1-oxopropyl]-N2'-deacetylmaytansine; cantuzumab mertansine; Immunoglobulin G1,anti-(mucin CanAg) (human-mouse monoclonal C242 heavy chain), disulfide withhuman-mouse monoclonal C242 lig; Immunoglobulin G1,anti-(mucin CanAg) (human-mouse monoclonal C242 heavy chain), disulfide withhuman-mouse monoclonal C242 light chain, dimer, tetraamide withN2'-[3-[(3-carboxy-1-methylpropyl)dithio]-1
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.