Биологическая активность
SC10914 is a highly мощный PARP ингибитор (PARP1 IC50 = 7.87 nM) with мощный anti-proliferative activity against human BRCA deficient tumor cells (MDA-MB-436, BRCA1 deficient, IC50 = 4.03 nM, Capan-1 BRCA2 deficient, IC50 = 11.66 nM) and PTEN deficient tumor cells (HGC-27,PTEN deficient, IC50 = 0.35 μM). SC10914 showed мощный anti-tumor activity in BRCA1/2 mutant tumor models and better pharmacokinetics profile has the potential to be selected as the clinical candidate for the treatment of treatment of BRCA1/2 deficient cancers.
Оригинал на английском
SC10914 is a highly potent PARP inhibitor (PARP1 IC50 = 7.87 nM) with potent anti-proliferative activity against human BRCA deficient tumor cells (MDA-MB-436, BRCA1 deficient, IC50 = 4.03 nM, Capan-1 BRCA2 deficient, IC50 = 11.66 nM) and PTEN deficient tumor cells (HGC-27,PTEN deficient, IC50 = 0.35 μM). SC10914 showed potent anti-tumor activity in BRCA1/2 mutant tumor models and better pharmacokinetics profile has the potential to be selected as the clinical candidate for the treatment of treatment of BRCA1/2 deficient cancers.
Химические свойства
- CAS №
- 76985-08-5
- Брутто-формула
- C₁₅H₁₅NO₂
- Мол. масса
- 241.29 г/моль
- SMILES
- C1(C2C=CC=CC=2)C=CC(CC(N)C(O)=O)=CC=1
- Синонимы
- 3-([1,1'-Biphenyl]-4-yl)-2-aminopropanoic acid; 2-Amino-3-(4-biphenylyl)propanoic Acid; [1,1'-Biphenyl]-4-propanoicacid, a-amino-; 2-Amino-3-(biphenyl-4-yl)propanoic acid; 4-PHENYL-DL-PHENYLALANINE и ещё 9
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.