Биологическая активность
Micafungin, also known as FK463, is a polyene antifungal medication used to treat and prevent invasive fungal infections including candidemia, abscesses and esophageal candidiasis. It inhibits the production of beta-1,3-glucan, an essential component of fungal клетка walls. It received final approval from the U.S. Food and препарат Administration (FDA) on March 16, 2005. Micafungin works by way of concentration-dependent inhibition of 1,3-beta-D-glucan synthase resulting in reduced formation of 1,3-beta-D-glucan, which is an essential polysaccharide comprising one-third of the majority of Candida spp. клетка walls. This decreased glucan production leads to osmotic instability and thus клеточный lysis.
Оригинал на английском
Micafungin, also known as FK463, is a polyene antifungal medication used to treat and prevent invasive fungal infections including candidemia, abscesses and esophageal candidiasis. It inhibits the production of beta-1,3-glucan, an essential component of fungal cell walls. It received final approval from the U.S. Food and Drug Administration (FDA) on March 16, 2005. Micafungin works by way of concentration-dependent inhibition of 1,3-beta-D-glucan synthase resulting in reduced formation of 1,3-beta-D-glucan, which is an essential polysaccharide comprising one-third of the majority of Candida spp. cell walls. This decreased glucan production leads to osmotic instability and thus cellular lysis.
Химические свойства
- CAS №
- 235114-32-6
- Брутто-формула
- C₅₆H₇₁N₉O₂₃S
- Мол. масса
- 1270.27 г/моль
- SMILES
- CCCCCOC1=CC=C(C2=CC(C3=CC=C(C(N[C@H]4C[C@H]([C@H](NC([C@@H]5[C@H]([C@H](CN5C([C@H]([C@@H](CC(N)=O)O)NC([C@H]([C@@H]([C@H](C6=CC(OS(=O)(O)=O)=C(O)C=C6)O)O)NC([C@@H]7C[C@H](CN7C([C@H]([C@H](O)C)NC4=O)=O)O)=O)=O)=O)C)O)=O)O)O)=O)C=C3)=NO2)C=C1
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.