![Структурная формула AV-412, CAS 451493-31-5, формула C27H28N6OFCl.2[C7H8O3S]](../images/products/DC23948.png)
Биологическая активность
AV-412, also known as MP-412, is a second-generation, orally bioavailable dual киназы ингибитор with potential antineoplastic activity. EGFR/HER2 ингибитор AV-412 binds to and inhibits the epidermal growth factor рецептор (EGFR) and the human epidermal growth factor рецептор 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation киназы inhibitors. EGFR and HER2 are рецептор tyrosine kinases that play major roles in tumor клетка proliferation and tumor vascularization.
Оригинал на английском
AV-412, also known as MP-412, is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization.
Химические свойства
- CAS №
- 451493-31-5
- Брутто-формула
- C₂₇H₂₈N₆OFCl.₂[C₇H₈O₃S]
- Мол. масса
- 851.41 г/моль
- SMILES
- O=S(C1=CC=C(C)C=C1)(O)=O.C=CC(NC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2C#CC(N5CCN(C)CC5)(C)C)=O.O=S(C6=CC=C(C)C=C6)(O)=O
- Синонимы
- 2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl); MP-412; AV 412; N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide,4-methylbenzenesulfonic acid; MP412 и ещё 49
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.