Биологическая активность
PDI ингибитор 16F16 is a protein disulfide isomerase (PDI) ингибитор, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from клетка death triggered by Aβ peptide. The actions of this ингибитор helped to identify a new mechanism in which a клетка death pathway is regulated by protein misfolding via PDI upregulation.
Оригинал на английском
PDI inhibitor 16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation.
Химические свойства
- CAS №
- 922507-80-0
- Брутто-формула
- C₁₆H₁₇ClN₂O₃
- Мол. масса
- 320.77 г/моль
- SMILES
- ClCC(N1CCC2C3=CC=CC=C3NC=2C1(C)C(OC)=O)=O
- Синонимы
- 1H-Pyrido[3,4-b]indole-1-carboxylic acid,2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-, methyl ester; methyl 2-(2-chloroacetyl)-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole-1-carboxylate
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.