Биологическая активность
CRT-0066854 is a PKCι and PKCζ ингибитор. CRT0066854, was able to restore polarized morphogenesis in the dysplastic H-Ras spheroids. These results show that tightly regulated PKCι is required for normal-polarized morphogenesis in mammalian cells and that H-Ras and ErbB2 cooperate with PKCι for loss of polarization and dysplasia. The identification of a PKCι ингибитор that can restore polarized morphogenesis has implications for the treatment of Ras and ErbB2 driven malignancies.
Оригинал на английском
CRT-0066854 is a PKCι and PKCζ inhibitor. CRT0066854, was able to restore polarized morphogenesis in the dysplastic H-Ras spheroids. These results show that tightly regulated PKCι is required for normal-polarized morphogenesis in mammalian cells and that H-Ras and ErbB2 cooperate with PKCι for loss of polarization and dysplasia. The identification of a PKCι inhibitor that can restore polarized morphogenesis has implications for the treatment of Ras and ErbB2 driven malignancies.
Химические свойства
- CAS №
- 1438881-19-6
- Брутто-формула
- C₂₄H₂₇Cl₂N₅S
- Мол. масса
- 488.48 г/моль
- Синонимы
- CRT0066854; CRT-0066854; CRT 0066854; CRT-0066854 HCl
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.