Биологическая активность
CRANAD-2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-fold fluorescence intensity increase, a 90 nm blue shift (from 805 to 715 nm), and a large increase in quantum yield. Moreover, this probe also shows a high affinity for Abeta aggregates (K(d) = 38.0 nM), a reasonable log P value (log P = 3), considerable stability in serum, and a weak interaction with albumin. After intravenous injection of this probe, 19-month-old Tg2576 mice exhibited significantly higher relative signal than that of the control mice over the same period of time.
Химические свойства
- CAS №
- 1193447-34-5
- Брутто-формула
- C₂₃H₂₅BF₂N₂O₂
- Мол. масса
- 410.26 г/моль
- SMILES
- CN(C)C1=CC=C(C=C1)\C=C/C2O[B-](F)(F)O\C(=C/C=C3C=CC(=[N+](C)C)C=C3)C=2
- Синонимы
- CRANAD 2; CRANAD-2; (T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-?O3,?O5]difluoroboron
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.