Биологическая активность
Tenidap, also known as CP-66248, is a COX/5-LOX ингибитор and cytokine-modulating anti-inflammatory препарат candidate that was under development by Pfizer as a promising potential treatment for rheumatoid arthritis, but Pfizer halted development after marketing approval was rejected by the FDA in 1996 due to liver and kidney toxicity, which was attributed to metabolites of the препарат with a thiophene moiety that caused oxidative damage.
Оригинал на английском
Tenidap, also known as CP-66248, is a COX/5-LOX inhibitor and cytokine-modulating anti-inflammatory drug candidate that was under development by Pfizer as a promising potential treatment for rheumatoid arthritis, but Pfizer halted development after marketing approval was rejected by the FDA in 1996 due to liver and kidney toxicity, which was attributed to metabolites of the drug with a thiophene moiety that caused oxidative damage.
Химические свойства
- CAS №
- 120210-48-2
- Брутто-формула
- C₁₄H₉ClN₂O₃S
- Мол. масса
- 320.75 г/моль
- Синонимы
- CP-66,248; CP 66,248; CP66,248; CP-66248; CP 66248 и ещё 2
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.