Биологическая активность
Nafoxidine, also known as PNU-0011100 and CP-5600, is a partial estrogen антагонист. Nafoxidine competes with endogenous estrogen for связывание to specific estrogen receptors. This agent also inhibits angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF); paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces oxidative stress, protein киназы C and calcium signaling.
Оригинал на английском
Nafoxidine, also known as PNU-0011100 and CP-5600, is a partial estrogen antagonist. Nafoxidine competes with endogenous estrogen for binding to specific estrogen receptors. This agent also inhibits angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF); paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces oxidative stress, protein kinase C and calcium signaling.
Химические свойства
- CAS №
- 1847-63-8
- Брутто-формула
- C₂₉H₃₂ClNO₂
- Мол. масса
- 462.03 г/моль
- Синонимы
- CP-5600; CP5600; CP 5600; PNU-0011100; PNU 0011100 и ещё 3
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.