Биологическая активность
Selfotel, also known as CGS-19755 and CPDD 0027, is a competitive NMDA антагонист. Selfotel directly competes with glutamate for связывание to the рецептор. Initial studies showed it to have anticonvulsant, anxiolytic, analgesic and neuroprotective effects, and it was originally researched for the treatment of stroke, but subsequent animal and human studies showed phencyclidine-like effects, as well as limited efficacy and evidence for possible neurotoxicity under some conditions, and so clinical development was ultimately discontinued.
Оригинал на английском
Selfotel, also known as CGS-19755 and CPDD 0027, is a competitive NMDA antagonist. Selfotel directly competes with glutamate for binding to the receptor. Initial studies showed it to have anticonvulsant, anxiolytic, analgesic and neuroprotective effects, and it was originally researched for the treatment of stroke, but subsequent animal and human studies showed phencyclidine-like effects, as well as limited efficacy and evidence for possible neurotoxicity under some conditions, and so clinical development was ultimately discontinued.
Химические свойства
- CAS №
- 110347-85-8
- Брутто-формула
- C₇H₁₄NO₅P
- Мол. масса
- 223.16 г/моль
- SMILES
- O=C([C@@H]1NCC[C@H](CP(O)(O)=O)C1)O
- Синонимы
- CGS-19755; CGS 19755; CGS19755; CPDD 0027; CPDD-0027 и ещё 2
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.