Биологическая активность
CAY10505 is a phosphatidylinositol 3-киназы-γ ингибитор , was found to significantly improve acetylcholine-induced endothelium dependent relaxation, serum nitrate and (or) nitrite level, glutathione level, and the vascular endothelial lining in hypertensive rats. CAY10505 , may improve hypertension-associated vascular endothelial dysfunction. Inhibition of PI3Kγ might be a useful approach in the therapeutics of vascular endothelium dysfunction.
Оригинал на английском
CAY10505 is a phosphatidylinositol 3-kinase-γ inhibitor , was found to significantly improve acetylcholine-induced endothelium dependent relaxation, serum nitrate and (or) nitrite level, glutathione level, and the vascular endothelial lining in hypertensive rats. CAY10505 , may improve hypertension-associated vascular endothelial dysfunction. Inhibition of PI3Kγ might be a useful approach in the therapeutics of vascular endothelium dysfunction.
Химические свойства
- CAS №
- 1218777-13-9
- Брутто-формула
- C₁₄H₈FNO₃S
- Мол. масса
- 289.28 г/моль
- SMILES
- O=C(NC/1=O)SC1=C\C2=CC=C(C3=CC=C(F)C=C3)O2
- Синонимы
- CAY10505; CAY 10505; CAY10505
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.