Биологическая активность
Symadex, also known as imidazoacridone; XLS-002 and C-1311, is a member of the novel imidazoacridinone family of anticancer agents. Imidazoacridone has shown activity in experimental tumour models both in vitro and in nude mice. C-1311 at the EC(99) dose delayed progression of cells through the S phase which was followed by G2 arrest. C-1311 does not induce rapid apoptosis in HT-29 cells, instead препарат exposure leads to prolonged G2 arrest followed by G2 to M transit and клетка death during mitosis in the process of mitotic catastrophe.
Оригинал на английском
Symadex, also known as imidazoacridone; XLS-002 and C-1311, is a member of the novel imidazoacridinone family of anticancer agents. Imidazoacridone has shown activity in experimental tumour models both in vitro and in nude mice. C-1311 at the EC(99) dose delayed progression of cells through the S phase which was followed by G2 arrest. C-1311 does not induce rapid apoptosis in HT-29 cells, instead drug exposure leads to prolonged G2 arrest followed by G2 to M transit and cell death during mitosis in the process of mitotic catastrophe.
Химические свойства
- CAS №
- 138154-39-9
- Брутто-формула
- C₂₀H₂₂N₄O₂
- Мол. масса
- 350.42 г/моль
- Синонимы
- C-1311, C1311; C 1311; XLS-002; XLS 002; XLS002 и ещё 2
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.