Биологическая активность
Biotin-PEG6-amine is PEG derivative containing a biotin group and a terminal primary amine group. The amine group can be coupled to carboxyl groups or 5'phosphate groups to form stable amide bonds. The hydrophilic PEG spacer increases solubility in aqueous media and increases membrane impermeability of the molecules conjugated to the biotin compound. It also helps to minimize steric hindrance involved with the связывание to avidin molecules. Therefore, Biotin-PEG-amines can be useful in the development of антитело препарат conjugates.
Оригинал на английском
Biotin-PEG6-amine is PEG derivative containing a biotin group and a terminal primary amine group. The amine group can be coupled to carboxyl groups or 5'phosphate groups to form stable amide bonds. The hydrophilic PEG spacer increases solubility in aqueous media and increases membrane impermeability of the molecules conjugated to the biotin compound. It also helps to minimize steric hindrance involved with the binding to avidin molecules. Therefore, Biotin-PEG-amines can be useful in the development of antibody drug conjugates.
Химические свойства
- Брутто-формула
- C₂₄H₄₆N₄O₈S
- Мол. масса
- 550.71 г/моль
- SMILES
- O=C1N[C@@]2([H])CS[C@@H](CCCCC(NCCOCCOCCOCCOCCOCCOCCN)=O)[C@@]2([H])N1
- Синонимы
- Biotin-PEG6-amine
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
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