Биологическая активность
Biotin-PEG6-Maleimide is a PEG derivative containing a biotin group and a maleimide group for labeling and crosslinking cysteines and other sulfhydryls. The maleimide group reacts specifically with sulfhydryl groups (at pH 6.5-7.5) to form a stable, irreversible thioether linkage. The hydrophilic PEG spacer increases solubility in aqueous media and increases membrane impermeability of the molecules conjugated to the biotin compound. It also helps to minimize steric hindrance involved with the связывание to avidin molecules.
Оригинал на английском
Biotin-PEG6-Maleimide is a PEG derivative containing a biotin group and a maleimide group for labeling and crosslinking cysteines and other sulfhydryls. The maleimide group reacts specifically with sulfhydryl groups (at pH 6.5-7.5) to form a stable, irreversible thioether linkage. The hydrophilic PEG spacer increases solubility in aqueous media and increases membrane impermeability of the molecules conjugated to the biotin compound. It also helps to minimize steric hindrance involved with the binding to avidin molecules.
Химические свойства
- Брутто-формула
- C₃₁H₅₁N₅O₁₁S
- Мол. масса
- 701.83 г/моль
- SMILES
- O=C1N[C@@]([H])([C@]([H])(CS2)N1)[C@@H]2CCCCC(NCCOCCOCCOCCOCCOCCOCCNC(CCN3C(C=CC3=O)=O)=O)=O
- Синонимы
- Biotin-PEG6-Maleimide; Biotin-PEG6-Mal; Biotin Functionalized, Biotin-PEG-Maleimide, Heterobifunctional PEGs, Maleimide Functionalized, Maleimide-PEG-Biotin,
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
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