Биологическая активность
Bialaphos is a natural non-селективный phytotoxin produced by certain Streptomyces species. It is a pro-toxin, a tripeptide that is converted in vivo to the active agent phosphinothricin, which is a glutamine analog. L-Phosphinothricin inhibits glutamine synthetase (Ki = 6.1 μM), resulting in accumulation of ammonium and disruption of primary metabolism. The bacterial bar gene encodes a phosphinothricin acetyltransferase, which confers resistance to phosphinothricin.3 Bialaphos is used in the selection of transgenic plants that express the bar gene, usually under the control of a constitutively active viral promoter.
Оригинал на английском
Bialaphos is a natural non-selective phytotoxin produced by certain Streptomyces species. It is a pro-toxin, a tripeptide that is converted in vivo to the active agent phosphinothricin, which is a glutamine analog. L-Phosphinothricin inhibits glutamine synthetase (Ki = 6.1 μM), resulting in accumulation of ammonium and disruption of primary metabolism. The bacterial bar gene encodes a phosphinothricin acetyltransferase, which confers resistance to phosphinothricin.3 Bialaphos is used in the selection of transgenic plants that express the bar gene, usually under the control of a constitutively active viral promoter.
Химические свойства
- Брутто-формула
- C₁₁H₂₁N₃NaO₆P
- Мол. масса
- 345.26 г/моль
- SMILES
- C[C@@H](C([O-])=O)NC([C@H](C)NC(C(N)CCP(CO)=O)=O)=O.[Na+]
- Синонимы
- Bilanafos-sodium; MW 801; SF 1293; Bialaphos sodium
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
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