Биологическая активность
Benzonatate, also known as Tessalon and KM-65, is a sodium channel protein антагонист. Benzonatate's mechanism of action is thought to be anesthesia of vagal sensory nerve fibers that mediate cough. Vagal sensory neurons highly express the Nav1.7 subtype of voltage-gated sodium channels, and inhibition of this channel inhibits the cough reflex.
Оригинал на английском
Benzonatate, also known as Tessalon and KM-65, is a sodium channel protein antagonist. Benzonatate's mechanism of action is thought to be anesthesia of vagal sensory nerve fibers that mediate cough. Vagal sensory neurons highly express the Nav1.7 subtype of voltage-gated sodium channels, and inhibition of this channel inhibits the cough reflex.
Химические свойства
- CAS №
- 104-31-4
- Брутто-формула
- C₃₀H₅₃NO₁₁
- Мол. масса
- 603.75 г/моль
- SMILES
- O=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCOC)C1=CC=C(NCCCC)C=C1
- Синонимы
- Benzonatate; Tessalon; KM65; KM 65; KM-65 и ещё 2
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.