Биологическая активность
Bimolane is a topoisomerase II ингибитор. Bimolane has been widely used in China as an anti-neoplastic agent and for the treatment of psoriasis. Bimolane is also a leukemogenic agent and is thought to exert its effects through the inhibition of topoisomerase II. The results of enzyme and DNA titration assays indicate that inhibition of topoisomerase II by bimolane occurred through interactions with DNA, similar to the mechanism seen with the epipodophyllotoxin-type inhibitors. These results provide evidence that bimolane is an ингибитор of topoisomerase II in vitro.
Оригинал на английском
Bimolane is a topoisomerase II inhibitor. Bimolane has been widely used in China as an anti-neoplastic agent and for the treatment of psoriasis. Bimolane is also a leukemogenic agent and is thought to exert its effects through the inhibition of topoisomerase II. The results of enzyme and DNA titration assays indicate that inhibition of topoisomerase II by bimolane occurred through interactions with DNA, similar to the mechanism seen with the epipodophyllotoxin-type inhibitors. These results provide evidence that bimolane is an inhibitor of topoisomerase II in vitro.
Химические свойства
- CAS №
- 74550-97-3
- Брутто-формула
- C₂₀H₃₂N₆O₆
- Мол. масса
- 452.51 г/моль
- SMILES
- O=C(CN(CCN1CC(N(CN2CCOCC2)C(C1)=O)=O)C3)N(CN4CCOCC4)C3=O
- Синонимы
- AT-1727; AT1727; AT 1727; CCRIS 7574; CCRIS7574 и ещё 3
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.