Биологическая активность
Amantadine is a препарат that has U.S. Food and препарат Administration approval for use both as an antiviral and an anti-parkinsonian препарат. Amantadine is a weak антагонист of the NMDA-type glutamate рецептор, increases dopamine release, and blocks dopamine reuptake. Amantadine probably does not inhibit MAO enzyme. Moreover, the mechanism of its antiparkinsonian effect is poorly understood.[citation needed] The препарат has many effects in the brain, including release of dopamine and norepinephrine from nerve endings. It appears to be a weak NMDA рецептор антагонист as well as an anticholinergic, specifically a nicotinic alpha-7 антагонист like the similar pharmaceutical memantine.
Оригинал на английском
Amantadine is a drug that has U.S. Food and Drug Administration approval for use both as an antiviral and an anti-parkinsonian drug. Amantadine is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. Amantadine probably does not inhibit MAO enzyme. Moreover, the mechanism of its antiparkinsonian effect is poorly understood.[citation needed] The drug has many effects in the brain, including release of dopamine and norepinephrine from nerve endings. It appears to be a weak NMDA receptor antagonist as well as an anticholinergic, specifically a nicotinic alpha-7 antagonist like the similar pharmaceutical memantine.
Химические свойства
- CAS №
- 768-94-5
- Брутто-формула
- C₁₀H₁₇N
- Мол. масса
- 151.25 г/моль
- Синонимы
- ADS-5102, EXP 105-1; EXP-105-1; GP 38026; Influenol; Midantan и ещё 11
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.