Биологическая активность
4'-bromo-resveratrol, a brominated analog of resveratrol, shows significant anticancer properties through its unique capacity to inhibit SIRT1 and SIRT3 simultaneously. In melanoma models, it alters клеточный metabolism by targeting mitochondrial function, leading to клетка cycle arrest and induction of programmed клетка death. This multimodal mechanism suggests potential applications in overcoming treatment resistance.
Оригинал на английском
4'-bromo-resveratrol, a brominated analog of resveratrol, shows significant anticancer properties through its unique capacity to inhibit SIRT1 and SIRT3 simultaneously. In melanoma models, it alters cellular metabolism by targeting mitochondrial function, leading to cell cycle arrest and induction of programmed cell death. This multimodal mechanism suggests potential applications in overcoming treatment resistance.
Химические свойства
- CAS №
- 1224713-90-9
- Брутто-формула
- C₁₄H₁₁BrO₂
- Мол. масса
- 291.14 г/моль
- SMILES
- BrC1C=CC(/C=C/C2=CC(O)=CC(O)=C2)=CC=1
- Синонимы
- 5-[(E)-2-(4-Bromophenyl)vinyl]benzene-1,3-diol; ALBB-014979; BB 0262672; CHEMBL2208038; FT-0683942 и ещё 3
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 4°C for 1 года, -20°C for more than 2 года
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.