Биологическая активность
3'2'-cGAMP (c[A(2',5')pG(3',5')p]) disodium is the disodium of 3'2'-cGAMP). 3'2'-cGAMP (c[A(2',5')pG(3',5')p]) is a cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) isomer. 3'2'-cGAMP exhibits high selectivity for Drosophila STING (dSTING), activating the dSTING-NF-κB signaling pathway, inducing the expression of Sting-regulated genes (Srg) and conferring a мощный antiviral state in vivo. 3'2'-cGAMP is resistant to cleavage by viral poxins. 3'2'-cGAMP can be used for the study of viral infections.
Оригинал на английском
3'2'-cGAMP (c[A(2',5')pG(3',5')p]) disodium is the disodium of 3'2'-cGAMP). 3'2'-cGAMP (c[A(2',5')pG(3',5')p]) is a cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) isomer. 3'2'-cGAMP exhibits high selectivity for Drosophila STING (dSTING), activating the dSTING-NF-κB signaling pathway, inducing the expression of Sting-regulated genes (Srg) and conferring a potent antiviral state in vivo. 3'2'-cGAMP is resistant to cleavage by viral poxins. 3'2'-cGAMP can be used for the study of viral infections.
Химические свойства
- Брутто-формула
- C₂₀H₂₂N₁₀Na₂O₁₃P₂
- Мол. масса
- 718.37 г/моль
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.