Биологическая активность
2'2'-cGAMP, a synthetic CDN, binds STING in the immune response, inducing IFN-β. 2'2'-cGAMP binds weaker связывание to STING than 2'3'-cGAMP. Emavusertib tosylate is an orally active ингибитор for IRAK4 (IC50=57 nM) and FLT3. Emavusertib tosylate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to клетка apoptosis. Emavusertib tosylate exhibits antitumor activity in mouse model.
Оригинал на английском
2'2'-cGAMP, a synthetic CDN, binds STING in the immune response, inducing IFN-β. 2'2'-cGAMP binds weaker binding to STING than 2'3'-cGAMP. Emavusertib tosylate is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib tosylate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib tosylate exhibits antitumor activity in mouse model.
Химические свойства
- CAS №
- 1465774-27-9
- Брутто-формула
- C₂₀H₂₄N₁₀O₁₃P₂
- Мол. масса
- 674.41 г/моль
- SMILES
- O[C@H]1[C@](O[P](O)(OC[C@@]([C@H]2O)([H])O[C@](N3C4=NC=NC(N)=C4N=C3)([H])[C@]2([H])O5)=O)([H])[C@](O[C@]1([H])CO[P]5(O)=O)([H])N6C(NC(N)=NC7=O)=C7N=C6
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- 2 года -20°C порошок, 2 недели 4°C в ДМСО, 6 мес. -80°C в ДМСО
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.