Биологическая активность
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) ингибитор and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2[1]. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration[2]. Zinc Protoporphyrin has anti-cancer activity[3].
Оригинал на английском
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2[1]. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration[2]. Zinc Protoporphyrin has anti-cancer activity[3].
Химические свойства
- CAS №
- 15442-64-5
- Брутто-формула
- C₃₄H₃₂N₄O₄-₂.Zn+₂
- Мол. масса
- 626.03 г/моль
- SMILES
- C=CC1=C(C)C2=CC3=NC(=CC4=NC(=CC5=C(C=C)C(=C(C=C1[N-]2)N5)C)C(=C4CCC(=O)O)C)C(=C3C)CCC(=O)[O-].[Zn+2]
- Синонимы
- Zinc protoporphyrin; Zinc protoporphyrin IX; Zinc Protoporphyrin-9; ZINC(II) PROTOPORPHYRIN; Protoporphyrin IX zinc(II) и ещё 3
3D-структура молекулы
Вращайте мышью · Колесо — масштаб
Хранение и физические свойства
- Условия хранения
- -20°C, sealed storage, away from moisture Publication: [1]. Park C, et al. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. Mar Drugs. 2019 Apr 13;17(4). [2]. Mwangi MN, et al. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. BMC Med. 2014 Nov 26;12:229. [3]. Nowis D, et al. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice. BMC Cancer. 2008 Jul 11;8:197.
Безопасность и документация
Только для научно-исследовательского применения. Не предназначено для использования у пациентов или в качестве лекарственного средства.